With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29943-42-8,Dihydro-2H-pyran-4(3H)-one,as a common compound, the synthetic route is as follows.
To a solution of 8a (5.Og, 50mmol) in THF (25mL) cooled to O0C, was added a suspension Of LiAlH4 (3.8g, O.lmol) in THF (5OmL) slowly. The resulting mixture was stirred at O0C for 30min, then was added water (3.8mL), followed by aqueous 15% NaOH (3.8mL) and water (1 1.4mL). The mixture was filtered and the solid was washed with ethyl ester (70mLchi2). The combined filtrate was evaporated to afford 8b (5.09g, 99%).
As the paragraph descriping shows that 29943-42-8 is playing an increasingly important role.
Reference£º
Patent; XCOVERY, INC.; WO2008/88881; (2008); A1;,
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