With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1172623-99-2,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
Step 0: tert-Butyl [(2R,3S)-2-(2,5-difluorophenyl)-5-oxotetrahydro-2H-pvran-3 -yflcarbamateTo 46.8 kg (142 mol) of tert-butyl [(2R,35)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro- 2H-pyran-3-yl]carbamate in a stirred vessel was added acetonitrile (150 kg), acetic acid (50 kg), and water (25 kg). After dissolving at room temperature, the solution was cooled to 0 C and RuC13?3H20 (250 g, 956 mmol) in water (50 kg) was added under nitrogen. Then, NaBrO3 (11.7kg, 77.5 mol) was added in six portions every 1 .5h under nitrogen. After stirring at 0 C for 6h,2-propanol (31 kg) was added over 30 mm. at 0 C. Then, water (720 kg) was added at this temperature over 5h. The resulting slurry was stirred overnight, filtered, and cake washed with water. The solids were then dried under vacuum at 40-60 C to give tert-butyl [(2R,35)-2-(2,5- difluorophenyl)-5-oxotetrahydro-2H-pyran-3 -yl]carbamate.
1172623-99-2, As the paragraph descriping shows that 1172623-99-2 is playing an increasingly important role.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; ARROYO, Itzia; KRUEGER, Davida; CHEN, Ping; MOMENT, Aaron; BIFTU, Tesfaye; SHEEN, Faye; ZHANG, Yanfeng; MERCK SHARPE & DOHME LTD.; WO2013/3249; (2013); A1;,
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