873397-34-3, Tetrahydro-2H-pyran-3-carboxylic acid is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
873397-34-3, Benzyl-N-[(5S)-6-(1,3-benzothiazol-2-yl)-6-oxo-5-(tetrahydropyran-3-carbonylamino)hexyl]carbamate (18a) To a solution of tetrahydropyran-3-carboxylic acid (108 mg, 829.58 mumol, 1.20 eq) in THF (5 mL) were added HATU (390 mg, 1.03 mmol, 1.48 eq) and DIPEA (270 mg, 2.09 mmol, 3.02 eq) under 0¡ã C. After being stirred for 0.5 h under 0¡ã C., benzyl-N-[(5S)-5-amino-6-(1,3-benzothiazol-2-yl)-6-oxo-hexyl]carbamate hydrochloride (300 mg, 691.32 mumol, 1.00 eq) was added and the resulting mixture was stirred at 28¡ã C. for 4.5 h. LC-MS indicated the reaction completed. The mixture was diluted with H2O (15 mL*2) and extracted with EA (20 mL*2). The combined organic layers were washed with H2O (20 mL), dried over Na2SO4, filtered and concentrated to give benzyl-N-[(5S)-6-(1,3-benzothiazol-2-yl)-6-oxo-5-(tetrahydropyran-3-carbonylamino)hexyl]carbamate (700 mg, crude) as a yellow solid. It was used directly for next step without further purification.
The synthetic route of 873397-34-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Cortexyme, Inc.; KONRADI, Andrei; DOMINY, Stephen S.; CRAWFORD LYNCH, Casey; COBURN, Craig; VACCA, Joseph; (91 pag.)US2016/96830; (2016); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics