Related Products of 10343-06-3. Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 10343-06-3, Name is 2,3,4,6-Tetra-o-acetyl-D-glucopyranose. In a document type is Patent, introducing its new discovery.
Hydrogen phosphorous acid monoester intermediates synthetic sugar-1-mono phosphoric acid method (by machine translation)
The invention belongs to the field of chemical synthesis and relates to synthesis of glycosyl-1-monophosphate. The method disclosed by the invention comprises the following steps of 1, performing a reaction between imidazole and phosphorus trichloride to obtain phosphite tri-imidazole, performing a reaction between the phosphite tri-imidazole and an acetylated sugar raw material of which the end position is deprotected and carrying out in-situ hydrolysis to obtain corresponding glycosyl-1-hydrogen phosphite monoester; 2, carrying out silylation on the glycosyl-1-hydrogen phosphite monoester by N,O-bi(trimethylsilyl)acetamide to obtain a trialkylphosphite intermediate, carrying out oxidation on an organic alkali/iodine simple substance system and carrying out in-situ hydrolysis to obtain glycosyl-1-monophosphate protected by acetyl; 3, removing an acetyl protecting group through sodium methylate and obtaining corresponding the high-purity glycosyl-1-monophosphate through sephadex chromatographic purification and ion exchange. According to the method disclosed by the invention, the glycosyl-1-monophosphate is obtained through the three steps and the total yield can reach 75 percent to 85 percent. Loss caused by benzyl removing by hydrogenation in a conventional method is avoided. The method disclosed by the invention is particularly suitable for preparing a great amount of glycosyl-1-monophosphate.
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Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics