A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 50675-18-8, Name is Tetrahydropyran-4-carbaldehyde, molecular formula is C6H10O2. In a Article£¬once mentioned of 50675-18-8, Recommanded Product: Tetrahydropyran-4-carbaldehyde
Discovery and Characterization of CD12681, a Potent RORgamma Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis
With possible implications in multiple autoimmune diseases, the retinoic acid receptor-related orphan receptor RORgamma has become a sought-after target in the pharmaceutical industry. Herein are described the efforts to identify a potent RORgamma inverse agonist compatible with topical application for the treatment of skin diseases. These efforts culminated in the discovery of N-(2,4-dimethylphenyl)-N-isobutyl-2-oxo-1-[(tetrahydro-2H-pyran-4-yl)methyl]-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonamide (CD12681), a potent inverse agonist with in vivo activity in an IL-23-induced mouse skin inflammation model.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Recommanded Product: Tetrahydropyran-4-carbaldehyde, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 50675-18-8, in my other articles.
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics