The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.31608-22-7, Name is 2-(4-Bromobutoxy)tetrahydro-2H-pyran, molecular formula is C9H17BrO2. In a Article£¬once mentioned of 31608-22-7, Product Details of 31608-22-7
The naturally occurring (6Z)-(¡À)-2-methoxy-6-hexadecenoic acid (1) and (6Z)-(¡À)-2-methoxy-6-octadecenoic acid (2) were synthesized in 7?8 steps with 38 and 13% overall yields, respectively, by using an acetylide coupling approach, which made it possible to obtain a 100% cis-stereochemistry for the double bonds. In a similar fashion, the acetylenic analogs (¡À)-2-methoxy-6-hexadecynoic acid (3) and (¡À)-2-methoxy-6-octadecynoic acid (4) were also synthesized in 6?7 steps with 48 and 16% overall yields, respectively. The antibacterial activity of acids 1?4 was determined against clinical isolates of methicillin-resistant Staphylococcus aureus (ClMRSA) and Escherichia coli. Among the series of compounds, acid 4 was the most active bactericide towards CIMRSA displaying IC50s (half maximal inhibitory concentrations) between 17 and 37?mug/mL, in sharp contrast to the 6-octadecynoic acid, which was not bactericidal at all. On the other hand, acids 1 and 3 were the only acids that displayed antibacterial activity towards E. coli., but 1 stood out as the best candidate with an IC50 of 21?mug/mL. The critical micelle concentrations (CMCs) of acids 1?4 were also determined. The C18 acids 2 and 4 displayed a five-fold lower CMC (15?20?mug/mL) than the C16 analogs 1 and 3 (70?100?mug/mL), indicating that 4 exerts its antibacterial activity in a micellar state. None of the studied acids were inhibitory towards S. aureus DNA gyrase discounting this type of enzyme inhibition as a possible antibacterial mechanism. It was concluded that the combination of alpha-methoxylation and C-6 unsaturation increases the bactericidal activity of the C16 and C18 FA towards the studied bacterial strains. Acids 1 and 4 stand out as viable candidates to be used against E. coli and CIMRSA, respectively.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Product Details of 31608-22-7, you can also check out more blogs about31608-22-7
Reference£º
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics