Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, get their minds active, and encourage them to do something that doesn’t involve a screen. 50675-18-8, C6H10O2. A document type is Article, introducing its new discovery., name: Tetrahydropyran-4-carbaldehyde
Synthesis and biological evaluation of a new series of hexahydro-2 H-pyrano[3,2-c ]quinolines as novel selective sigma1 receptor ligands
The synthesis and pharmacological activity of a new series of hexahydro-2H-pyrano[3,2-c]quinoline derivatives as potent sigma1 receptor (sigma1R) ligands are reported. This family, which does not contain the highly basic amino group usually present in other sigma1R ligands, showed high selectivity over the sigma2 receptor (sigma2R). The activity was shown to reside in only one of the four possible diastereoisomers, which exhibited a perfect match with known sigma1R pharmacophores. A hit to lead program based on a high-throughput screening hit (8a) led to the identification of compound 32c, with substantially improved activity and physicochemical properties. Compound 32c also exhibited a good ADMET (absorption, distribution, metabolism, excretion, toxicity) profile and was identified as a sigma1R antagonist on the basis of its analgesic activity in the mouse capsaicin and formalin models of neurogenic pain.
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics