In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum. Quality Control of: 6-Butyltetrahydro-2H-pyran-2-one, Quality Control of: 6-Butyltetrahydro-2H-pyran-2-one, C9H16O2. A document type is Article, introducing its new discovery.
A high-yielding stereoselective method for forming spiroketals from simple ketoallylic diols is reported. Employing catalytic [PdCl2(MeCN) 2] in THF at 0 C, these dehydrative cyclization reactions require only mild conditions to produce vinyl-substituted spiroketals in high yields after brief reaction times with water as the only byproduct. Using this method, the stereochemical information embedded at the nucleophile is transmitted “down-the-chain” and efficiently sets the stereochemistry at both the anomeric carbon atom and the newly formed allylic stereocenter. Down-the-chain: Rapid, high-yielding dehydrative spiroketalization of ketoallylic diols is achieved by efficient catalysis with [PdCl 2(MeCN)2]. The reactions are highly selective for most substrates, with the chiral information of a single stereocenter being communicated, and cyclization occurring, in a “down-the-chain” fashion. Further stereochemical control can be gained by the incorporation of a chiral allylic alcohol (see scheme). Copyright
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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics