Tag: M.W:100-200

Related Products of 50675-18-8, An article , which mentions 50675-18-8, molecular formula is C6H10O2. The compound – Tetrahydropyran-4-carbaldehyde played an important role in people’s production and life.

Metal-free one-pot alpha-carboxylation of primary alcohols

An efficient metal-free procedure for the formal alpha-carboxylation of primary alcohols has been developed. The method involves a one-pot oxidation/Passerini/hydrolysis sequence and provides access to alpha-hydroxy acids bearing a broad range of functional groups. A minor modification to the reaction conditions extends the range of accessible products to alpha-hydroxy esters.

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 61363-56-2, Name is 2H-Pyran-3,5(4H,6H)-dione, molecular formula is C5H6O3. In a Patent，once mentioned of 61363-56-2, Quality Control of: 2H-Pyran-3,5(4H,6H)-dione

Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives

The present invention is a compound of formula 1wherein R1 is halogen or lower alkyl; R2 is hydrogen, lower alkyl, cycloalkyl, ?(CH2)m-phenyl, wherein the phenyl ring may be substituted by lower alkoxy, or is ?(CH2)m-indolyl; R3 is ?C(O)O-lower alkyl, ?C(O)OH, or a five membered heteroaromatic group, which rings may be substituted by lower alkyl or cycloalkyl; n is 0, 1 or 2; m is 0, 1 or 2; or a pharmaceutically acceptable acid addition salt thereof. Compound I shows high affinity and selectivity for GALA A alpha5 receptor binding sites.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Quality Control of: 2H-Pyran-3,5(4H,6H)-dione. In my other articles, you can also check out more blogs about 61363-56-2

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2081-44-9, Name is Tetrahydro-2H-pyran-4-ol, molecular formula is C5H10O2. In a Article，once mentioned of 2081-44-9, Computed Properties of C5H10O2

Discovery and optimization of a novel spiropyrrolidine inhibitor of beta-secretase (BACE1) through fragment-based drug design

The aspartyl protease beta-secretase, or BACE, has been demonstrated to be a key factor in the proteolytic formation of Abeta-peptide, a major component of plaques in the brains of Alzheimers disease (AD) patients, and inhibition of this enzyme has emerged as a major strategy for pharmacologic intervention in AD. An X-ray-based fragment screen of Pfizers proprietary fragment collection has resulted in the identification of a novel BACE binder featuring spiropyrrolidine framework. Although exhibiting only weak inhibitory activity against the BACE enzyme, the small compound was verified by biophysical and NMR-based methods as a bona fide BACE inhibitor. Subsequent optimization of the lead compound, relying heavily on structure-based drug design and computational prediction of physiochemical properties, resulted in a nearly 1000-fold improvement in potency while maintaining ligand efficiency and properties predictive of good permeability and low P-gp liability.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2081-44-9 is helpful to your research., Computed Properties of C5H10O2

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 51673-83-7, Name is Tetrahydro-2H-pyran-2-carboxylic acid, molecular formula is C6H10O3. In a Patent，once mentioned of 51673-83-7, name: Tetrahydro-2H-pyran-2-carboxylic acid

MODIFIED EPOXIDISED NATURAL RUBBER

The invention concerns a method of modifying an epoxidised natural rubber that helps improve grafting performance. The method comprises: – reacting an epoxidised natural rubber with a system consisting of – a carboxylic acid of general formula (I) in which R represents a group likely to interact with a reinforcing filler and – an imidazole of general formula (II) in which, – R1 represents a hydrocarbon group or a hydrogen atom, – R2 represents a hydrocarbon group, R3 and R4 represent, independent of each other, a hydrogen atom or a hydrocarbon group, or indeed R3 and R4 form a ring together with the carbon atoms of the imidazole ring to which they bond, – then curing at a temperature greater than 120C.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: Tetrahydro-2H-pyran-2-carboxylic acid. In my other articles, you can also check out more blogs about 51673-83-7

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of 134419-59-3. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 134419-59-3, Name is Tetrahydro-2H-pyran-4-yl methanesulfonate. In a document type is Patent, introducing its new discovery.

PYRAZOLOPYRIDINES AS INHIBITORS OF THE KINASE LRRK2

A compound of formula la or formula 1b, or a pharmaceutically acceptable salt or ester thereof, wherein R1 is selected from: aryl; heteroaryl; -NHR3; fused aryl-C4-7-heterocycloalkyl; – CONR4R5; -NHCOR6; -C3-7-cycloalkyl; -0-C3-7-cycloalkyl; -NR3R6; and optionally substituted -C1-6 alkyl; wherein said aryl, heteroaryl, fused aryl-C4-7-heterocycloalkyl and C4-7- heterocycloalkyl are each optionally substituted; Q is CN, halogen, or is selected from C1-6-alkyl, C3-7-cycloalkyl, heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted with one or more substituents A; R2 is selected from hydrogen, aryl, C1-6-alkyl, C2-6-alkenyl,C3-7-cycloalkyl, heteroaryl, C4-7 heterocycloalkyl and halogen, wherein said C1-6-alkyl,, Cz-B-alkenyl, aryl, heteroaryl and C4-7-heterocycloalkyl are each optionally substituted; R3 is selected from aryl, heteroaryl, C4-7-heterocycloalkyl, C3-7- cycloalkyl, fused aryl-C-heterocycloalkyl and C1-6-alkyl, each of which is optionally substituted; R4 and R5 are each independently hydrogen, or optionally substituted C3-7- cycloalkyl, aryl, heteroaryl, C1-6-alkyl or C3-6-heterocycloalkyl; or R4 and R5 together with the N to which they are attached form a C3-6-heterocycloalkyl ring; each R6 is independently selected from C1-6-alkyl, C3-7 cycloalkyl, C-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; each R7 is selected from hydrogen, optionally substituted C1-6-alkyl and C3-7-cycloalkyl; each of R8 and R9 is independently hydrogen or optionally substituted C1-6-alkyl; or R8 and R9 together with the N to which they are attached form a C4-6-heterocycloalkyl; each R10 is selected from C3-7- cycloalkyl and optionally substituted C1-6-alkyl; each R11 is independently selected from C1-6-alkyl, C3-7-cycloalkyl, C1-6-alkyl-C3-7-cycloalkyl, C4-7-heterocycloalkyl, aryl and heteroaryl, each of which is optionally substituted; A is selected from halogen, – NR4S02R5, -CN, -OR6, -NR4R5, -NR7R11, hydroxyl, -CF3, -CONR4R5, -NR4COR5, -NR7(CO)NR4R5, -N02, -C02H, -C02R6, -S02R6, -S02NR4R5, -NR4COR5 ,-NR4COOR5, 6-alkyl and -COR6. Further aspects relate to pharmaceutical compositions, therapeutic uses and process for preparing compounds of formulae 1a and 1b

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Electric Literature of 2081-44-9, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 2081-44-9, Name is Tetrahydro-2H-pyran-4-ol, molecular formula is C5H10O2. In a Patent，once mentioned of 2081-44-9

NOVEL DIARYLALKENE DERIVATIVES AND NOVEL DIARYLALKANE DERIVATIVES

The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating pain etc. comprising the compound represented by the following general formula (1) or its analogue to a patient in need of such treatment: wherein, A represents CH=CH, etc., a, b, c and d represents CH etc., R1, R2, R3, R4, R5 and R6 represents H etc., V–W represents C=C, etc., n represents 0 to 3, Y1 represents O etc., B represents–(CH2)vCHR21 wherein v is 0 to 3, R21 represents H, a lower alkyl group or the like, etc., G represents–CO–, a covalent bond, etc., m is 0 to 6, R7 and R8 represents H, a lower alkyl group,–COR18a,–COOR20 wherein R18a and R20 each represents a lower alkyl group or the like, etc.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2081-44-9 is helpful to your research., Electric Literature of 2081-44-9

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Synthetic Route of 5631-96-9. Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 5631-96-9, Name is 2-(2-Chloroethoxy)tetrahydro-2H-pyran. In a document type is Article, introducing its new discovery.

Efficient deprotection of tetrahydropyranyl ethers by silica sulfuric acid

Treatment of tetrahydropyranyl (THP) ethers with silica sulfuric acid in methanol provides a simple and efficient process for deprotection of these ethers and the parent alcohols are obtained in excellent yields.

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.2081-44-9, Name is Tetrahydro-2H-pyran-4-ol, molecular formula is C5H10O2. In a Patent，once mentioned of 2081-44-9, category: Tetrahydropyrans

The present invention relates to novel pharmaceutical compositions comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 2081-44-9 is helpful to your research., category: Tetrahydropyrans

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

Reference of 40191-32-0, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 40191-32-0, Name is Tetrahydro-2H-pyran-4-carbonyl chloride, molecular formula is C6H9ClO2. In a Article，once mentioned of 40191-32-0

A novel class of small molecule NPY Y5 antagonists based around an azabicyclo[3.1.0]hexane scaffold was identified through modification of a screening hit. Structure-activity relationships and efforts undertaken to achieve a favourable pharmacokinetic profile in rat are described.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 40191-32-0 is helpful to your research., Reference of 40191-32-0

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

In an article, published in an article, once mentioned the application of 220641-87-2, Name is N-Methyltetrahydro-2H-pyran-4-amine,molecular formula is C6H13NO, is a conventional compound. this article was the specific content is as follows.Recommanded Product: 220641-87-2

Described herein are neuroactive steroids or a pharmaceutically acceptable salt thereof. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. Also provided are pharmaceutical compositions comprising a compound described herein and methods of use and treatment, e.g., such as for inducing sedation and/or anesthesia.

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Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics