Tag: M.W:300-400

499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11, belongs to tetrahydropyrans compound, is a common compound. In a patnet, once mentioned the new application about 499-40-1, Product Details of 499-40-1

Olefin coordination in copper(I) complexes of bis(2-pyridyl)amine

Complexes of the type [Cu(H-dpa)(olefin)]BF4 for ethylene (1), propylene (2), 1-butene (3), 1-hexene (4), 1-octene (5), cis-2-octene (6), trans-2-octene (7), cis-3-octene (8), trans-3-octene (9), 2-norbornylene (10), 1,5-cyclooctadiene (11), styrene (12), cis-stilbene (13), trans-stilbene (14), and Ph2CCH2 (15) have been prepared and characterized by 1H and 13C NMR, FTIR, and TGA. The crystal structures have been determined for compounds 5, 6, 8, and 10-13. With the exception of compound 11, copper atoms in each complex are coordinated to the two pyridine nitrogen atoms and the appropriate olefin; consistent with a pseudo three-coordinate Cu(I) cation. Compound 11 has a second weaker pi-interaction resulting in a distorted tetrahedral geometry. Steric hindrance between the olefin and H-dpa manifests as both a twisting of the olefin out of the plane of the H-dpa ligand and a concomitant folding of the H-dpa ligand. The shifts in the nuN-H IR spectral band for H-dpa ligand are consistent with the formation of N-H…F hydrogen bonded interactions observed in the crystal structures. The 1H and 13C NMR spectra of [Cu(H-dpa)(olefin)]BF4 exhibit an upfield shift in the olefin signal as compared to free olefin. A comparison of the Deltadelta values for terminal olefins shows that the similarity of binding for H2CCHR (R = CnH2n+1, n = 1-6) mitigates any preferential complexation of various terminal olefins using the H-dpa ligand. For octenes there is a significant difference in binding between a terminal and internal olefin, but there is little preference between binding for different internal olefins and only a modest difference between the cis and trans isomers of the same olefin. A good correlation exists between the 1H NMR Deltadelta values and the TGA data, confirming that the shift of the olefin NMR resonances upon coordination is associated with the binding strength of the complex. Ab initio calculations using four different method/basis set combinations on the structure of [Cu(H-dpa)(1-octene)]+ were compared with the crystal structure.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Product Details of 499-40-1. In my other articles, you can also check out more blogs about 499-40-1

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10343-06-3, Name is 2,3,4,6-Tetra-o-acetyl-D-glucopyranose, molecular formula is C14H20O10. In a Article，once mentioned of 10343-06-3, category: Tetrahydropyrans

Enhanced efficacy of 7-hydroxy-3-methoxycadalene via glycosylation in in vivo xenograft study

7-Hydroxy-3-methoxycadalene, isolated from Zelkova serrata Makino, was confirmed as a biologically active natural compound. In this study, the efficacy of cadalene as an anticancer agent was tested. In order to address the poor physicochemical properties of cadalene, we designed and synthesized glycosylated cadalene derivatives for improved solubility and efficient drug delivery as a potential prodrug. In vitro cell viability assays confirmed that glycosylated cadalenes were less toxic and more soluble than cadalene. In an in vivo xenograft study in mice, the oral administration of glycosylated cadalenes caused a significant reduction in tumor size.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 10343-06-3 is helpful to your research., category: Tetrahydropyrans

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10343-06-3, Name is 2,3,4,6-Tetra-o-acetyl-D-glucopyranose, molecular formula is C14H20O10. In a Article，once mentioned of 10343-06-3, category: Tetrahydropyrans

PREPARATION OF GLYCOSYL HALIDES UNDER NEUTRAL CONDITIONS

The anomeric hydroxyl group of various furanose and pyranose hemiacetals can be replaced by a fluorine, chlorine, bromine or iodine atom under neutral conditions using haloenamines.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.category: Tetrahydropyrans. In my other articles, you can also check out more blogs about 10343-06-3

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

64519-82-0, Name is (3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol, molecular formula is C12H24O11, belongs to tetrahydropyrans compound, is a common compound. In a patnet, once mentioned the new application about 64519-82-0, HPLC of Formula: C12H24O11

Effect of isomalt as novel binding agent on compressibility of poorly compactable paracetamol evaluated by factorial design

Tablets containing paracetamol were prepared by wet granulation. The model drug, paracetamol (API) and the diluent, milled isomalt (IM) were applied in different ratios where the granulation liquid was kept constant in each sample. The purpose of the study was to investigate the effect of wet granulation with milled isomalt on the tabletting properties of poorly compressible paracetamol. The results of tabletting process and the tablet characteristics were evaluated with 32 type face-centered full factorial design. The API:IM ratio (X1) and compression force (X2) were selected as independent variables. The dependent variables were as follows: the parameters of the tabletting process – lubrication coefficient (R-value), relative elasticity, friction work – and characteristics of the dosage form such as tablet hardness, friability, disintegration time, tensile strength. The results indicated that milled isomalt has an advantageous effect on both the process of compression and the tablet characteristics – due to its binder properties. Furthermore an optimal composition of the API and the diluent is to be found according to the compression process and the dosage form.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C12H24O11. In my other articles, you can also check out more blogs about 64519-82-0

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11. In a Article，once mentioned of 499-40-1, Quality Control of: (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

Herein, we report the synthesis, molecular structures and bioevaluation of two different cationic copper(ii) complexes with the third generation quinolone antibacterial agent levofloxacin (lvx) and 2N-substituted ligands 2,2?-dipyridylamine (bipyam) and bathophenanthroline (BPhen). The molecular structures of [Cu(lvx)(bipyam)Cl]+ (1) and [Cu(lvx)(BPhen)Cl]+ (2) exhibit distorted square-pyramidal coordination environments around the copper atoms with tau values of 0.137 in (1) and 0.0316 in (2). Their binding interaction modes towards calf-thymus (CT) DNA were examined by a series of spectroscopy measurements including electronic absorption, viscosity measurements, circular dichroism and fluorescence spectroscopy. Also, the quenching mechanism, thermodynamic parameters (DeltaG, DeltaH and DeltaS) and total number of binding sites per albumin (n) were explored at different temperatures (25, 30 and 35 C) by fluorescence quenching experiments. These complexes quench the intrinsic fluorescence of serum albumins and complex 2 exhibits the highest binding constant values at 25 C (KBSA = 7.77 ± 0.02 × 105 M-1 in the case of bovine serum albumin (BSA) and KHSA = 1.55 ± 0.01 × 105 M-1 in the case of human serum albumin (HSA)). Molecular docking simulations on the crystal structures of CT DNA, BSA and HSA were employed in order to study the ability of the complexes to bind to these target macromolecules. The in vitro bio-efficacies of the complexes were screened against nine different microorganisms to examine their antibacterial potential. Furthermore, the complexes were also subjected to cytotoxicity tests against the MCF-7 cancer cell line and the results indicated that both complexes have superior cytotoxicity to the currently used chemotherapeutic agent cisplatin.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 499-40-1 is helpful to your research., Quality Control of: (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11. In a Article，once mentioned of 499-40-1, Safety of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

The title compound, Ni3(dpa)4Cl2 (dpa = di(2-pyridyl)amido anion), first reported 30 years ago, structurally characterized in 1991, has been obtained in two new crystal forms, Ni3(dpa)4Cl2·2CH2Cl 2 (tetragonal, space group I4, with a = 27.3046(7) A, c = 12.2452(2) A, Z = 8) and Ni3(dpa)4Cl2·THF (orthorhombic, space group Pccn, with a = 12.673(1) A, b = 14.138(3) A, c = 23.890(2) A, Z = 4). They have been examined structurally, and the magnetic properties of one of them determined from 2 to 300 K. Also the proton NMR spectrum has been recorded. These data allow the following conclusions to be drawn: (1) the molecular structure is invariant in the three crystalline forms and has a symmetrical chain of nickel atoms, (2) the terminal metal atoms each have two unpaired electrons, while the central one is typical of diamagnetic square-planar NiII complexes, (3) the magnetic moments of the two terminal nickel(II) ions display antiferromagnetic coupling, with 2J = -108 cm-1, and (4) the Ni3 chain remains symmetrical in solution.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Safety of (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 499-40-1, in my other articles.

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.81025-04-9, Name is Lactitol monohydrate, molecular formula is C12H26O12. In a Patent，once mentioned of 81025-04-9, Safety of Lactitol monohydrate

The invention relates to a novel crystalline anhydrous lactitol, a process for the preparation thereof, and the use thereof. The novel crystalline anhydrous lactitol belongs to the monoclinic crystal system and has the unit cell constants: (a)=7.614 A; (b)=10.757 A; (c)=9.370 A and beta=108.2. Its melting point is between 149 C. and 152 C., water content below 0.5% and lactitol content more than 99%; it has a low hygroscopicity.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Safety of Lactitol monohydrate, you can also check out more blogs about81025-04-9

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10343-06-3, Name is 2,3,4,6-Tetra-o-acetyl-D-glucopyranose, molecular formula is C14H20O10. In a Article，once mentioned of 10343-06-3, Application In Synthesis of 2,3,4,6-Tetra-o-acetyl-D-glucopyranose

Gold(iii)-catalysed glycosylation reaction has been developed by employing a new and easily accessible leaving group synthesized from ethyl cyanoacetate. Several nucleophiles like alcohols, thiols, allyltrimethylsilane, trimethylsilyl azide and triethylsilane have been reacted to make the corresponding glycosides in good yields and with marginal to excellent alpha-selectivity. This journal is

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data.Application In Synthesis of 2,3,4,6-Tetra-o-acetyl-D-glucopyranose, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 10343-06-3, in my other articles.

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

10343-06-3, Name is 2,3,4,6-Tetra-o-acetyl-D-glucopyranose, molecular formula is C14H20O10, belongs to tetrahydropyrans compound, is a common compound. In a patnet, once mentioned the new application about 10343-06-3, HPLC of Formula: C14H20O10

The invention provides a structure shown in formula I amide derivative or its pharmaceutically acceptable salt, the compound or its pharmaceutically acceptable salt has significant inhibition HIV protease and activity of the reverse transcriptase; toxicity study demonstrated its good officinal property, show that the compound as the anti-aids drugs have good application prospect. According to an embodiment of the experimental data can be known, the compounds of this invention HIV – 1 protease and HIV – 1 reverse transcriptase all have inhibitory activity, but also have low cytotoxicity. The compounds of this invention or its pharmaceutically acceptable salts have become the at the same time inhibiting HIV protease and reverse transcriptase of double-target inhibitors. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.HPLC of Formula: C14H20O10. In my other articles, you can also check out more blogs about 10343-06-3

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics

499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11, belongs to tetrahydropyrans compound, is a common compound. In a patnet, once mentioned the new application about 499-40-1, name: (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

The two-step syntheses of the substituted di(2-pyridyl)amine ligands (dpa), dpa-CH2CO2H (1) and dpa-PhCO2H (2), are described. Ligands 1 and 2 are successfully coupled to the amino acid phenylalanine, yielding the derivatives 4 and 6, respectively. Four Cu II(dpa)2 complexes, [Cu(dpa-CH2CO 2tBu)2(NO3)2] (3Cu), [Cu(dpa-CH2CO-PheOMe)2(H2O)2] (NO3)2·2MeOH (4Cu), [Cu(dpa-PhCO 2Me)2 (MeOH)2](ClO4)2 (5Cu) and [Cu(dpa-PhCO-PheOMe)2(ClO4) 2] (6Cu) have been prepared and characterized, including their single crystal X-ray structures. Fluorescence emission at UV (for 3 and 4) or blue (for 5 and 6) wavelengths of the free ligands is preserved in the corresponding Cu complexes, although with lower intensity. X-band EPR spectra of 4Cu and 6Cu both revealed one axial CuII signal with hyperfine and superhyperfine splittings. Complexes 4Cu and 6Cu are chiral inorganic complexes with amino acid bioconjugates that may serve as nucleoside analogs in modified peptide nucleic acids (PNA). Wiley-VCH Verlag GmbH & Co. KGaA, 2007.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.name: (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal. In my other articles, you can also check out more blogs about 499-40-1

Reference：
Tetrahydropyran – Wikipedia,
Tetrahydropyran – an overview | ScienceDirect Topics