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COMBINATIONS COMPRISING HISTONE DEACETYLASE INHIBITORS

The invention relates to a combination of a compound of formula (I) or a pharmaceutically acceptable salt thereof, and at least one second agent selected from the group consisting of proteasome inhibitors, tumour immunotherapeutics or immunomodulatory agents, signal transduction pathway inhibitors, agents inhibiting the BCL2 family of proteins, agents inhibiting Mcl-1, poly (ADP-ribose) polymerase (PARP) Inhibitors, aromatase inhibitors, conventional cytotoxic agents or a miscellaneous agent selected from abiraterone, ARN-509 and MYC inhibitors.

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Tetrahydropyran – Wikipedia,
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Lewis-base Adducts of Group 11 Metal(I) Compounds. Part 58. Syntheses, X-Ray Structures, and Far-infrared Spectra of the Novel – (X=Cl or Br) Anion Salts of the + Cation and the Dimeric Iodide <(dpa)CuI2Cu(dpa)>

Reaction of copper(I) halides (CuX, X=Cl, Br, or I) in acetonitrile solution with di(2-pyridyl)amine (dpa) yields 1:1.5 adducts with the chloride and bromide, a 1:1 adduct with the iodide, and 1:2 adduct with the chloride.The compounds have been characterized by spectroscopic and single-crystal X-ray methods.The 1:1 iodide is a dimer, <(dpa)CuI2Cu(dpa)>, of a type familiar with other bidentate nitrogen base ligands, but the 1:1.5 complexes are ionic, formulated as +-, containing the first structurally characterized + cations and – anions, while the 1:2 chloride is -.In the + cation mean Cu-Ni is ca. 2.00 Angstroem, while in the – anions Cu-N is ca. 2.05 Angstroem and Cu-Cl and Cu-Br 2.369(2), 2.302(2), and 2.490(6), 2.439(6) Angstroem, respectively.The dpa ligand in all cases is essentially planar.The far i.r. spectra of the anions show bands at 214 cm-1 (chloride) and 160 cm-1 (bromide) which can be assigned to the asymetric stretching mode of the CuX2 unit.

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Tetrahydropyran – Wikipedia,
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Multi-dimensional systems built from dichromate anions – Syntheses, crystal structures, and magnetic properties

Three novel compounds with bridging dichromate anions with the formulae [Fe(4,4?-bpy)2Cr2O7]n (1), [Co(4,4?-bpy)2Cr2O7]n (2), and [Ni(dpa)2Cr2O7]¡¤H2O (3) (4,4?-bpy = 4,4?-bipyridine, dpa = 2,2?-dipyridylamine) have been synthesized and characterized. The isostructural compounds 1 and 2 belong to the monoclinic space group C2/c and have been shown to be three-dimensional polymers in which the dichromate anions connect neighboring layers formed by [M(4,4?-bpy)2]2+ (M = Fe, Co) units. Compound 3 is a metallacrown type compound, crystallizing in the monoclinic space group P2 1/n. Two chromate anions link two NiII centers forming a dinuclear entity. The uncoordinated oxygen atom of the dichromate anion forms a hydrogen bond with the N-H unit of dpa resulting in a two-dimensional network. Measurements of magnetic susceptibilities indicate the presence of antiferromagnetic interactions in 1 and 2 whereas the exchange coupling between the NiII ions in 3 is ferromagnetic. The IR and UV/Vis spectra of the above complexes have also been investigated. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

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Tetrahydropyran – Wikipedia,
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Synthesis of targetable cationic amphiphiles

Cationic amphiphiles 1a-1c, with monosaccharide at the omega-position of the hydrocarbon tails, were synthesized by utilization of Schmidt’s trichloroacetimidate procedure for the glycosylation step and application of the commercially available 3,5-dihydroxybenzyl alcohol as a scaffold for the attachment of double hydrocarbon tails. Application of the Zemplen condition for O-deacetylation in the presence of base-sensitive benzyl bromide was found to be efficient. The synthetic route provides an entry for the synthesis of versatile quaternary ammonium amphiphiles having the cell targeting glycosyl ligands.

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Tetrahydropyran – Wikipedia,
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New enzymatic protecting group techniques for peptide and carbohydrate chemistry

New methods are reported to establish enzymatic techniques for the chemo- and regioselective functionalization of carbohydrates, peptides and glycoconjugates.The N-terminal deprotection of peptides is achieved via hydrolysis of phenylacetamides, employing penicillin G acylase as biocatalyst.The C-terminal carboxyl function of peptides and O-glycopeptides is liberated by the lipase-mediated hydrolysis of heptyl esters.Penicillin G acylase and citrus acetylesterase are used to effect the chemo- and regioselective removal of phenylacetyl and acetyl blocking groups, respectively from differently protected carbohydrates.

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Tetrahydropyran – Wikipedia,
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SnCl4/Sn catalyzed chemoselective reduction of glycopyranosyl azides for the synthesis of diversely functionalized glycopyranosyl chloroacetamides

A method for the chemoselective reduction of glycopyranosyl azides using SnCl4 and tin metal as the reducing agent followed by in situ chloroacetylation of the synthesized glycopyranosyl amine was developed. This reaction is applicable to diversely functionalized glycopyranosyl azides for the synthesis of glycopyranosyl chloroacetamides.

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Tetrahydropyran – Wikipedia,
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The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.499-40-1, Name is (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal, molecular formula is C12H22O11. In a Article£¬once mentioned of 499-40-1, Quality Control of: (2R,3S,4R,5R)-2,3,4,5-Tetrahydroxy-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexanal

Mixed ligand Co(II), Ni(II) and Cu(II) complexes containing terephthalato ligands. Crystal structures of diaqua(2,2′-dipyridylamine)(terephthalato)metal(II) trihydrates (metal = cobalt or nickel)

A series of nine ternary Co(II), Ni(II) and Cu(II) complexes with some aromatic diamines and dianion of terephthalic acid (tpht) have been synthesized and characterized by elemental analysis, magnetic susceptibility measurements, IR and diffuse-reflectance spectroscopy. All compounds were obtained as microcrystalline solids, stable in air and insoluble in common solvents. Two of them, [M(tpht)(dipya)(H2O)2]¡¤3H2O [M = Co(II), Ni(II); dipya = 2,2′-dipyridylamine], were obtained as single crystals and their crystal structures have been determined by X-ray structure analysis. Both structures consist of discrete [M(tpht)(dipya)(H2O)2]2+ complex units with two H2O molecules in the trans position. Three additional H2O molecules together with coordinated H2O and O atoms from COO groups make a three-dimensional network of hydrogen bonds. Terephthalato ligands are coordinated by only one COO group, which acts as a chelating ligand. Central metal ions are in a distorted octahedral environment. Based on the above-mentioned analysis and known crystal structures, the possible structures and geometry of the complexes are discussed. All Co(II) and Ni(II) complexes are pseudooctahedral and mononuclear, with only one of the tpht COO groups coordinated in a chelate mode. Cu(II) complexes have probably distorted octahedral geometry with bridging role of tpht ions and monodentate or strongly asymmetric coordination of COO groups. (C) 2000 Elsevier Science Ltd.

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Synthesis of fully protected N-arylglycosylamines and factors affecting the configuration of C1-substituents of N-arylglycosylamines

An efficient method was reported for preparation of N-arylglycosyl-amines in aqueous THF under reflux in good yields. The factors affecting the configuration of C1-substituents of N-aryglycosylamines was investigated, that is, the influence of solvents, substituents of aromatic amines, and protecting groups of monosaccharides on the ratio of alpha- and beta-N-arylglycosylamines.

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Tetrahydropyran – Wikipedia,
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Organic-inorganic hybrid materials: Ligand influences on the structural chemistry of copper-vanadates

Hydrothermal reactions were used in the preparation of a series of bimetallic organic-inorganic hybrid materials of the M(II)/VxO y/organonitrogen ligand class. Compound 1, [{Cu2(bpa) 2(C2O4)}2V4O 12]¡¤H2O, is molecular, while [{Cu(terpy)} 2V6O17] (2), [Cu2(bpyrm)V 4O12] (4) and [{Cu(phen)(H2O) 2}VOF4(H2O)]¡¤2H2O (5) are two-dimensional, three-dimensional and one-dimensional, respectively (bpa = 2,2?-bipyridylamine; terpy = 2,2?:6,2?-terpyridine; bpyrm = 2,2?-bipyrimidine; phen = 1,10-phenanthroline). In contrast to the 2-D structure of 2, the Ni(II) analogue [{Ni(terpy)}2V4O 12]¡¤2H2O (3) is one-dimensional. The {V 4O12}4- cluster is a building block of structures 1, 3, and 4 while 2 is constructed from {V6O 17}4- rings.

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A blue luminescent star-shaped Znii complex that can detect benzene

Binding benzene: A novel blue luminescent star-shaped ZnII complex has been found to be able to detect benzene selectively by fluorescent quenching. This is attributed to the compound’s high affinity to benzene, as demonstrated in the crystal structure (see picture; yellow: benzene, red: zinc).

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Tetrahydropyran – Wikipedia,
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