Analyzing the synthesis route of 25637-16-5

25637-16-5, The synthetic route of 25637-16-5 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.25637-16-5,4-Bromotetrahydropyran,as a common compound, the synthetic route is as follows.

Step 1: To 4-bromotetrahydro-2H-pyran (10 g) in round bottom flask was added 10 N NaOH (15 ml). After heated at 90 C for 24 h, the aqueous layer was separated out leaving 3,6- dihydro-2H-pyran as the crude material.

25637-16-5, The synthetic route of 25637-16-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; JIA, Zhaozhong J.; KANE, Brian; XU, Qing; BAUER, Shawn M.; SONG, Yonghong; PANDEY, Anjali; DICK, Ryan; WO2013/78468; (2013); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics