With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1172623-99-2,tert-Butyl ((2R,3S)-2-(2,5-difluorophenyl)-5-hydroxytetrahydro-2H-pyran-3-yl)carbamate,as a common compound, the synthetic route is as follows.
1H (11.53 g, 35.03 mmol) was dissolved in dichloromethane (130 mL) Cooling to 0C ,Dess-Martin oxidant (29.72 g, 70.06 mmol) was added portionwise to the reaction solution, Naturally rose to room temperature for 4 hours. Cooling to 0C ,Saturated sodium bicarbonate solution (60 mL) was added dropwise to the reaction solution, stirred for 20 minutes,The organic phase was washed with saturated sodium bicarbonate solution (30 mL x 2), and the organic phase was dried over anhydrous sodium sulfate and dried over anhydrous sodium sulfate (60 mL x 3). The organic phase was washed with saturated sodium bicarbonate solution (30 mL x 2) , Filtered and concentrated by column chromatography (petroleum ether / ethyl acetate (v / v) = 10: 1-4: 1) to give white crystalline powder intermediate 1 (10.85 g, yield 94.7%). (30 mL x 2), and the solvent was concentrated to give a white solid, 1H (7.9 g, 84% yield).
1172623-99-2, As the paragraph descriping shows that 1172623-99-2 is playing an increasingly important role.
Reference£º
Patent; Sichuan Haisco Pharmaceutical Co.,Ltd.; FAN, JIANG; ZHANG, CHEN; PENG, FEI; WU, YE; FENG, JIANCHUAN; WANG, JIANMIN; ZHENG, SUXIN; WEI, YONGGANG; YE, FEI; (350 pag.)TW2017/8220; (2017); A;,
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