1240390-36-6, tert-Butyl ((3R,4R)-4-aminotetrahydro-2H-pyran-3-yl)carbamate is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
10554] A mixture of compound 30-A (553 mg, 2.556 mmol), the pyrone 6-B (619 mg, 2.556 mmol), and NaHCO3 (435 mg, 5.178 mmol) in water (5 mE) and ethanol (5 mE) was stirred at room temperature. After 30 mm, the reaction mixture was concentrated to remove most of the solvent and the residue was mixed with dichioromethane (about 40 mE) and stirred vigorously before drying (Mg504). The dried solution was concentrated. The residue was dissolved in Dichloromethane (2 mE) and treated with 4 N HC1 in dioxane (6 mE). Afier 40 mm, the mixture was concentrated and dried in vacuum overnight. A mixture of the residue and DI3U (1.9 mE, 12.71 mmol) in toluene (19 mE) was stirred at 1000 C. After 30 mm, the reaction mixture was cooled down to room temperature, dissolved in dichloromethane, and concentrated. The residue was purified by column chromatography on silica gel (40 g column) using ethyl acetate-20% methanol in ethyl acetate as eluents to obtain impure compound 30-C. The impure compound 30-C was dissolved in DMF and purified by preparative HPEC to get compound 30-C as 1:1 mixture with trifluoroacetic acid. ?H NMR (400 MHz, Chloroform-d) oe 9.92 (s, 1H), 8.33 (s, 1H), 7.67 (s, 1H), 4.51 (dt, J=12.2, 4.1 Hz, 1H), 4.21-4.04 (m, 3H), 3.95 (s, 3H), 3.84 (s, 3H), 3.73 (d, J=12.8 Hz, 1H), 3.54 (td, J=12.3, 2.2 Hz, 1H),2.24 (qd, J=12.6, 4.8 Hz, 1H), 1.94 (dd, J=13.1, 4.9 Hz, 1H). ECMS-ESI (mlz): [M+H] calculated for C,4H,7N205: 309. 11. found: 309.17.
1240390-36-6, The synthetic route of 1240390-36-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Gilead Sciences, Inc.; Bacon, Elizabeth M.; Cai, Zhenhong R.; Cottell, Jeromy J.; Ji, Mingzhe; Jin, Haolun; Lazerwith, Scott E.; Morganelli, Philip Anthony; Pyun, Hyung-jung; (101 pag.)US2016/176870; (2016); A1;,
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