With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125552-89-8,4-(Bromomethyl)tetrahydropyran,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of 1H-indole-5-carbonitrile (1.5 g, 10.56 mmol) in DMF (8 mL) were added KI (1.75 g, 10.56 mmol) followed by NaH (1.26 g, 31.68 mmol) in portion wise at 0 C and reaction mixture was stirred at the same temperature for 5 mm. After 5 mi 4-(bromomethyl) tetrahydro-2H-pyran (2.1 mL, 15.84 mmol) was added to reaction mixture at 0 C then stirred atrt for 4 h. Progress of the reaction was monitored by TLC. Reaction mixture was quenched withcrushed ice, stirred for 15 mm, solid obtained in the reaction mixture was filtered off, dried undervaccum to get the pale cream solid (yield: 2.25g, 88.9 %).1H NMR (400 IVIFIz, CDC13) 8.0 (s, 1H), 7.47-7.36 (m, 2H), 7.18 (d, J= 3.14 Hz, 1H), 6.58 (d, J= 3.0 Hz, 1H), 4.02 (d, J 7.29 Hz, 2H), 3.98 (d, J= 3.38 Hz, 2H), 3.38-3.28 (m, 2H), 2.10-2.05(m, 1H), 1.5 1-1.40 (m, 4H),LC-MS m/z (M): calculated 240; found (M+H): 241, 125552-89-8
As the paragraph descriping shows that 125552-89-8 is playing an increasingly important role.
Reference£º
Patent; BIOIMICS AB; KIRSEBOM, Lars; UPADHAYAYA, Ram Shankar; KETHIRI, Raghava Reddy; VIRTANEN, Anders; (241 pag.)WO2019/88910; (2019); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics