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220641-87-2, As the paragraph descriping shows that 220641-87-2 is playing an increasingly important role.

220641-87-2, N-Methyltetrahydro-2H-pyran-4-amine is a Tetrahydropyrans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 32 7V-Methyl-iV-(tetrahvdro-2H-pyran-4-v?-[2,l,31-benzothiadiazole-5-carboxamideN-Methyltetrahydro-2H-pyran-4-amine (0.4 g, 3.4 mmol), [2,l,3]-benzothiadiazole-5- carboxylic acid (0.23g, 1.4mmol ), DMAP (0.2 g: l.mmol), HOBT (0.2 g, 1.5 mmol), triethylamine (1.0 ml) and EDCI (Ig, 6.4mmol) were dissolved in DMF (30 ml). The mixture was stirred at room temperature for 18h and then concentrated under vacuum. Chloroform (100 ml) was added and the mixture washed with water (100 ml) and H2SO4 (^ pH 2) and NaHCO3 solution (100 ml). The aqueous was extracted with chloroform (100 ml) and the combined organics were dried (MgSO4), concentrated under vacuum, and the crude product was purified on a silica gel column eluting with chloroform/THF (90:10), to give the product as an oil which crystallized on standing. Mp = 106-108C, 1H NMR (300 MHz, CDCl3, rotamers) delta 8.06 (d, J = 9.0 Hz, IH); 8.01 (s, IH); 7.60 (d, J = 9.0 Hz, IH); 4.92-4.75 and 4.15-3.10 (m, 5H); 3.10-2.80 (m, 3H) and 2.05-1.50 ppm (s, 4H).

220641-87-2, As the paragraph descriping shows that 220641-87-2 is playing an increasingly important role.

Reference£º
Patent; CORTEX PHARMACEUTICALS, INC.; WO2008/143963; (2008); A1;,
Tetrahydropyran – Wikipedia
Tetrahydropyran – an overview | ScienceDirect Topics